Molecular ̄ip± ̄ops formed by overlapping Fis sites
نویسندگان
چکیده
The DNA-binding protein Fis frequently uses pairs of sites 7 or 11 base pairs (bp) apart. Two overlapping Fis sites separated by 11 bp are found in the Escherichia coli origin of chromosomal replication. Only one of these sites is bound by Fis at a time, so the structure is a molecular ̄ip± ̄op that could direct alternative ®ring of replication complexes in opposite directions. Alternatively, the ̄ip± ̄op could represent part of an on±off switch for replication. Because they can be used to create precise switched states, molecular ̄ip± ̄ops could be used as the basis of a novel molecular computer.
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تاریخ انتشار 2003